Warning: Diminished Antiplatelet Effect in Patients with Two Loss-of-function Alleles of the Cyp2c19 Gene
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چکیده
WARNING: DIMINISHED ANTIPLATELET EFFECT IN PATIENTS WITH TWO LOSS-OF-FUNCTION ALLELES OF THE CYP2C19 GENE See full prescribing information for complete boxed warning. • Effectiveness of Plavix depends on conversion to an active metabolite by the cytochrome P450 (CYP) system, principally CYP2C19. (5.1, 12.3) • Tests are available to identify patients who are CYP2C19 poor metabolizers. (12.5) • Consider use of another platelet P2Y12 inhibitor in patients identified as CYP2C19 poor metabolizers. (5.1)
منابع مشابه
Should Genetic Testing Be Done in All Patients Treated With Clopidogrel and Undergoing Percutaneous Coronary Intervention? CYP2C19 Genetic Testing Should Not Be Done in All Patients Treated With Clopidogrel Who Are Undergoing Percutaneous Coronary Intervention
Clopidogrel when added to aspirin reduces major vascular events in patients undergoing percutaneous coronary intervention (PCI).1 Recent reports have suggested that common genetic variants involving hepatic cytochrome P450 system enzymes that convert clopidogrel to its active metabolite are associated with an increased risk of cardiovascular events. Specifically, patients who are carriers of 1 ...
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متن کاملThe clopidogrel-statin interaction.
activity in influencing the antiplatelet effect of clopidogrel came from the work of Lau et al.4,5 Over a decade ago, those authors demonstrated that atorvastatin co-administration attenuated the antiplatelet effect of clopidogrel and the pharmacologic modulation of CYP 3A4 activity directly influenced the pharmacodynamic effect of clopidogrel. That ground breaking study opened the “Pandora’s b...
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